Commentary on epidemiological studies and intervention trials.

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چکیده

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Commentary on epidemiological studies and intervention trials.

Epidemiological studies have proved invaluable for identifying environmental risk factors and gene-environment interactions in the development of hypertension and other chronic diseases. Now, after several decades, the solid contributions of longitudinal and cross-national studies of random population samples are well established. The art and science of clinical trials have achieved a high leve...

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The paper by Aalen et al. is a timely discussion of an important topic. However, it conflates two concepts, frailty and heterogeneity, which are best kept apart. I would use the term frailty only when there is clear biological evidence that a fraction of the population is either exclusively at risk, or at vastly increased risk compared with the general population, of contracting a disease. An e...

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Clinical Trials and Intervention Studies

In a controlled observational cohort study, two groups of subjects are selected from two populations that (hopefully) differ in only one characteristic at the start. The groups of subjects are studied for a specific period and contrasted at the end of the study period. For instance, smokers and nonsmokers are studied for a period of 10 years, and at the end the proportions of smokers and nonsmo...

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Commentary: Balancing quantity and quality when designing epidemiological studies.

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ژورنال

عنوان ژورنال: Hypertension

سال: 1991

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.17.1_suppl.i34